Central Leptin Regulation of Obesity and Fertility

obesity, leptin and leptin receptors

Onm-2: Obesity and Female Fertility

Background: Infertility & Obesity have often been linked among of reproductive age. Obesity results in an increased production of Estrogen and Androgen, these hormonal imbalances interfere with ovulation, which of course is the basis of successful conception. Obesity is a characteristic of polycystic ovary syndrome (PCOS). Obesity is linked to several health conditions, including cardiovascular...

Leptin resistance and diet-induced obesity: central and peripheral actions of leptin.

Obesity is a chronic disease that represents one of the most serious global health burdens associated to an excess of body fat resulting from an imbalance between energy intake and expenditure, which is regulated by environmental and genetic interactions. The adipose-derived hormone leptin acts via a specific receptor in the brain to regulate energy balance and body weight, although this protei...

Bone mass regulation of leptin and postmenopausal osteoporosis with obesity.

BACKGROUND Leptin has been known to play a role in weight regulation through food intake and energy expenditure. Leptin also has an important role in bone metabolism. The role of leptin is determined by leptin receptors, either central or peripheral to the bones. DESIGN We discuss the role of leptin on bone and molecular genetics of osteoporosis in postmenopausal obese women. RESULTS The ro...

Central regulation of energy balance: inputs, outputs and leptin resistance.

The regulation of energy balance is complex and, in man, imprecise. Nevertheless, in many individuals intake and expenditure are balanced with <1% error with little or no conscious effect. Essential components of such a regulatory system are signals, leptin and insulin, that reflect the size of lipid stores. Leptin receptors signal via phosphatidylinositol 3-kinase (as do insulin receptors) and...